HOXA13

2L7Z320915398ENSG00000106031ENSMUSG00000038203P31271Q62424NM_000522NM_008264NP_000513NP_032290Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene. Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-genital syndrome, also known as hand-foot-uterus syndrome. This article incorporates text from the United States National Library of Medicine, which is in the public domain.