Hand–Schüller–Christian disease

Hand–Schüller–Christian disease is associated with multifocal Langerhans cell histiocytosis. Hand–Schüller–Christian disease is associated with multifocal Langerhans cell histiocytosis. It is associated with a triad of exophthalmos, lytic bone lesions (often in the skull), and diabetes insipidus (from pituitary stalk infiltration). It is named for the American pediatrician Alfred Hand Jr, the Austrian neurologist and radiologist Arthur Schüller, and the American internist Henry Asbury Christian, who described it in 1893, 1915/16 and 1919