Retinoic acid receptor alpha

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor that in humans is encoded by the RARA gene.1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13591419401ENSG00000131759ENSMUSG00000037992P10276Q6I9R7P11416NM_000964NM_001024809NM_001033603NM_001145301NM_001145302NM_001176528NM_001177302NM_001177303NM_009024NM_001361954NP_001138773.1NP_001169999NP_001170773NP_001170774NP_033050NP_001348883Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT (NCOR2), and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene.Retinoic acid receptor alpha has been shown to interact with:This article incorporates text from the United States National Library of Medicine, which is in the public domain.