Simmondsin is a component of jojoba seeds (pronounced 'ho-HO-bah') (Simmondsia chinensis). While it had been considered toxic due to jojoba seed meal causing weight loss in animals, in recent years its appetite suppressant effect has also been researched as a potential treatment for obesity. Several mechanisms of action are thought to be involved in the appetite suppressant effect. Simmondsin is a component of jojoba seeds (pronounced 'ho-HO-bah') (Simmondsia chinensis). While it had been considered toxic due to jojoba seed meal causing weight loss in animals, in recent years its appetite suppressant effect has also been researched as a potential treatment for obesity. Several mechanisms of action are thought to be involved in the appetite suppressant effect.