QRFP

347148227717ENSG00000188710ENSMUSG00000043102P83859Q8CE23NM_198180NM_183424NP_937823NP_906269RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein. RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein. The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.