Cytidine deaminase

1MQ097872269ENSG00000158825ENSMUSG00000028755P32320P56389NM_001785NM_028176NP_001776NP_082452Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.1mq0: Crystal Structure of Human Cytidine Deaminase Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation. Click on genes, proteins and metabolites below to link to respective articles.