Cistrome

The cistrome refers to 'the set of cis-acting targets of a trans-acting factor on a genome-wide scale, also known as the in vivo genome-wide location of or histone modifications'. The term cistrome is a portmanteau of cistr (from cistron) + ome (from genome). The term cistrome was coined by investigators at the Dana-Farber Cancer Institute and Harvard Medical School. The cistrome refers to 'the set of cis-acting targets of a trans-acting factor on a genome-wide scale, also known as the in vivo genome-wide location of or histone modifications'. The term cistrome is a portmanteau of cistr (from cistron) + ome (from genome). The term cistrome was coined by investigators at the Dana-Farber Cancer Institute and Harvard Medical School. Technologies such as chromatin immunoprecipitation combined with microarray analysis 'ChIP-on-chip' or with massively parallel DNA sequencing 'ChIP-Seq' have greatly facilitated the definition of the cistrome of transcription factors and other chromatin associated proteins.