Cathepsin S

1GLO, 1MS6, 1NPZ, 1NQC, 2C0Y, 2F1G, 2FQ9, 2FRA, 2FRQ, 2FT2, 2FUD, 2FYE, 2G6D, 2G7Y, 2H7J, 2HH5, 2HHN, 2HXZ, 2OP3, 2R9M, 2R9N, 2R9O, 3IEJ, 3KWN, 3MPE, 3MPF, 3N3G, 3N4C, 3OVX, 4P6E, 4P6G152013040ENSG00000163131ENSMUSG00000038642P25774O70370NM_004079NM_001199739NM_001267695NM_021281NP_001186668NP_004070NP_001254624NP_067256Cathepsin S is a protein that in humans is encoded by the CTSS gene. Transcript variants utilizing alternative polyadenylation signals exist for this gene.1glo: CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S1ms6: Dipeptide Nitrile Inhibitor Bound to Cathepsin S.1npz: Crystal structures of Cathepsin S inhibitor complexes1nqc: Crystal structures of Cathepsin S inhibitor complexes2c0y: THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S2f1g: Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide2fq9: Cathepsin S with nitrile inhibitor2fra: Human Cathepsin S with CRA-27934, a Nitrile Inhibitor2frq: Human Cathepsin S with Inhibitor CRA-268712ft2: Human Cathepsin S with Inhibitor CRA-297282fud: Human Cathepsin S with Inhibitor CRA-275662fye: Mutant Human Cathepsin S with irreversible inhibitor CRA-140132g6d: Human cathepsin S mutant with vinyl sulfone inhibitor CRA-140092g7y: Human Cathepsin S with inhibitor CRA-169812h7j: Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.2hh5: Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide2hhn: Cathepsin S in complex with non covalent arylaminoethyl amide.2hxz: Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)2op3: The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method Cathepsin S is a protein that in humans is encoded by the CTSS gene. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Cathepsin S is a member of the peptidase C1 family and is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation to the MHC class II. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. While a role in antigen presentation has long been recognized, it is now understood that cathepsin S has a role in itch and pain, or nociception . The nociceptive activity results from cathepsin S functioning as a signaling molecule via activation of protease-activated receptors 2 and 4 members of the G-protein coupled receptor family. Cathepsin S is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Cathepsin S is expressed by some epithelial cells. Its expression is markedly increased in human keratinocytes following stimulation with interferon-gamma and its expression is elevated in psoriatic keratinocytes due to stimulation by proinflammatory factors. In contrast, cortical thymic epithelial cells do not express cathepsin S.