CD151

97712476ENSG00000177697ENSMUSG00000025510P48509Q6ZNZ0O35566NM_139030NM_001039490NM_004357NM_139029NM_001111049NM_001111050NM_009842NP_004348.2NP_620598.1NP_620599.1NP_001104519NP_001104520NP_033972CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene. CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. CD151 has been shown to interact with CD46. This article incorporates text from the United States National Library of Medicine, which is in the public domain.