Chemoradiotherapy (CRT, CRTx) is the combination of chemotherapy and radiotherapy to treat cancer. Synonyms include radiochemotherapy (RCTx, RT-CT) and chemoradiation. Chemoradiotherapy (CRT, CRTx) is the combination of chemotherapy and radiotherapy to treat cancer. Synonyms include radiochemotherapy (RCTx, RT-CT) and chemoradiation. Chemoradiation can be concurrent (together) or sequential (one after the other). The chemotherapy component can be or include a radiosensitizing agent. Chemoradiotherapy as neoadjuvant therapy before surgery has been shown to be effective in Esophageal Cancer.