BRCC3

79184210766ENSG00000185515ENSMUSG00000031201P46736P46737NM_001018055NM_001242640NM_024332NM_001166457NM_001166459NM_145956NM_001358736NM_001358737NP_001018065NP_001229569NP_077308NP_001159929NP_001159931NP_666068NP_001345665NP_001345666Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene. Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene. This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants. BRCC3 has been shown to interact with BRE, BRCA2, RAD51, BRCA1, P53 and BARD1.