7-Dehydrocholesterol reductase

171713360ENSG00000172893ENSMUSG00000058454Q9UBM7O88455NM_001163817NM_001360NM_007856NP_001157289NP_001351NP_0318827-Dehydrocholesterol reductase, also known as DHCR7, is a protein that in humans is encoded by the DHCR7 gene. 7-Dehydrocholesterol reductase, also known as DHCR7, is a protein that in humans is encoded by the DHCR7 gene. The protein encoded by this gene is an enzyme catalyzing the production of cholesterol from 7-Dehydrocholesterol using NADPH. The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the ultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development. A deficiency is associated with Smith–Lemli–Opitz syndrome. Click on genes, proteins and metabolites below to link to respective articles. This article incorporates text from the United States National Library of Medicine, which is in the public domain.