Nodular sclerosis

Nodular sclerosis (or 'NSHL') is a form of Hodgkin's lymphoma that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands.aggressive: Sézary disease Nodular sclerosis (or 'NSHL') is a form of Hodgkin's lymphoma that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands. The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into 'nodular sclerosis type I' (NS I) and 'nodular sclerosis type II' (NS II), with the first subtype responding better to treatment.