Homothallic refers to the possession, within a single organism, of the resources to reproduce sexually; i.e., having male and female reproductive structures on the same thallus. The opposite sexual functions are performed by different cells of a single mycelium. Homothallic refers to the possession, within a single organism, of the resources to reproduce sexually; i.e., having male and female reproductive structures on the same thallus. The opposite sexual functions are performed by different cells of a single mycelium. It can be contrasted to heterothallic. It is often used to categorize fungi. In yeast, heterothallic cells have mating types a and α. An experienced mother cell (one that has divided at least once) will switch mating type every cell division cycle because of the HO allele.