Annexin A2

1W7B, 1XJL, 2HYU, 2HYV, 2HYW, 4DRW, 4FTG, 4HRH30212306ENSG00000182718ENSMUSG00000032231P07355P07356NM_001002857NM_001002858NM_001136015NM_004039NM_007585NP_001002857NP_001002858NP_001129487NP_004030NP_031611Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.1w7b: ANNEXIN A2: DOES IT INDUCE MEMBRANE AGGREGATION BY A NEW MULTIMERIC STATE OF THE PROTEIN.1xjl: Structure of human annexin A2 in the presence of calcium ions2hyu: Human Annexin A2 with heparin tetrasaccharide bound2hyv: Human Annexin A2 with heparin hexasaccharide bound2hyw: Human Annexin A2 with Calcium bound Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions.It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body. The ANXA2 gene, located at 15q22.2, has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Epigenetic regulation of Annexin A2 has been identified as a key determinant of mesenchymal transformation in brain tumors. Annexin A2 has been proposed to function inside the cell in sorting of endosomes and outside the cell in anticoagulant reactions. Annexin A2 has been shown to interact with Prohibitin, CEACAM1, S100A10, PCNA, complement Factor H, and a number of viral factors including the HPV16 minor capsid protein L2.