Early growth response protein 1

4R2A, 4R2C, 4R2D, 4X9J195813653ENSG00000120738ENSMUSG00000038418P18146P08046NM_001964NM_007913NP_001955NP_031939EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.1a1f: DSNR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GACC SITE)1a1g: DSNR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCGT SITE)1a1h: QGSR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCAC SITE)1a1i: RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCAC SITE)1a1j: RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCGT SITE)1a1k: RADR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GACC SITE)1a1l: ZIF268 ZINC FINGER-DNA COMPLEX (GCAC SITE)1aay: ZIF268 ZINC FINGER-DNA COMPLEX1f2i: COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA1jk1: Zif268 D20A Mutant Bound to WT DNA Site1jk2: Zif268 D20A mutant bound to the GCT DNA site1p47: Crystal Structure of tandem Zif268 molecules complexed to DNA1zaa: ZINC FINGER-DNA RECOGNITION: CRYSTAL STRUCTURE OF A ZIF268-DNA COMPLEX AT 2.1 ANGSTROMS EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice. The protein encoded by this gene belongs to the EGR family of Cys2His2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene. It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity. EGR-1 has also been found to regulate the expression of VAMP2 (a protein important for synaptic exocytosis). The DNA-binding domain of EGR-1 consists of three zinc finger domains of the Cys2His2 type.The amino acid structure of the EGR-1 zinc finger domain is given in this table, using the single letter amino acid code. The fingers 1 to 3 are indicated by f1 - f3. The numbers are in reference to the residues (amino acids) of alpha helix (there is no zero). The residues marked 'x' are not part of the zinc fingers, but rather serve to connect them all together. Amino acid key: Alanine (Ala, A), Arginine (Arg, R), Asparagine (Asn, N), Aspartic acid (Asp, D), Cysteine (Cys, C), Glutamic acid (Glu, E), Glutamine (Gln, Q), Glycine (Gly, G), Histidine (His, H), Isoleucine (Ile, I), Leucine (Leu, L), Lysine (Lys, K), Methionine (Met, M), Phenylalanine (Phe, F), Proline (Pro, P), Serine (Ser, S), Threonine (Thr, T), Tryptophan (Trp, W), Tyrosine (Tyr, Y), Valine (Val, V) The crystal structure of DNA bound by the zinc finger domain of EGR-1 was solved in 1991, which greatly aided early research in zinc finger DNA-binding domains. The human EGR-1 protein contains (in its unprocessed form) 543 amino acids with a molecular weight of 57.5 kDa, and the gene is located on the chromosome 5.