ALAS1

21111655ENSG00000023330ENSMUSG00000032786P13196Q8VC19NM_000688NM_001304443NM_001304444NM_199166NM_001291835NM_020559NP_000679NP_001291372NP_001291373NP_954635NP_001278764NP_065584Delta-aminolevulinate synthase 1 also known as ALAS1 is a protein that in humans is encoded by the ALAS1 gene. ALAS1 is an aminolevulinic acid synthase. Delta-aminolevulinate synthase 1 also known as ALAS1 is a protein that in humans is encoded by the ALAS1 gene. ALAS1 is an aminolevulinic acid synthase. Delta-aminolevulinate synthase catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2. This article incorporates text from the United States National Library of Medicine, which is in the public domain.