N-myc-interactor

911164685ENSG00000123609ENSMUSG00000026946Q13287Q8WTW2O35309NM_004688NM_001141948NM_001141949NM_019401NP_004679NP_004679.2NP_001135420NP_001135421NP_062274N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene. N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene. NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. NMI (gene) has been shown to interact with BRCA1, IFI35, Myc, and STAT5A, and TUBA3C.