HOXD13

323915433ENSG00000128714ENSMUSG00000001819P35453P70217NM_000523NM_008275NP_000514NP_032301Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly and Brachydactyly. The product of the mouse Hoxd13 gene plays a role in axial skeleton development and forelimb morphogenesis. This article incorporates text from the United States National Library of Medicine, which is in the public domain.