RNF4

2EA6, 2XEU, 4PPE604719822ENSG00000063978ENSMUSG00000029110P78317Q9QZS2NM_002938NM_001185009NM_001185010NM_011278NM_001304269NM_001304270NP_001171938NP_001171939NP_002929NP_001291198NP_001291199NP_035408RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene. RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene. The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. RNF4 has been shown to interact with TCF20, PATZ1 and Androgen receptor.