USO1

2W3C861556041ENSG00000138768ENSMUSG00000029407O60763Q9Z1Z0NM_001290049NM_003715NM_019490NP_001276978NP_003706NP_062363General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene. General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene. The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GOLGA2, and giantin in a sequential manner. USO1 has been shown to interact with: