Lymphoid enhancer-binding factor 1

2LEF, 3OUW, 3OUX5117616842ENSG00000138795ENSMUSG00000027985Q9UJU2P27782NM_001130713NM_001130714NM_001166119NM_016269NM_001276402NM_001276403NM_010703NP_001124185NP_001124186NP_001159591NP_057353NP_057353.1NP_001263331NP_001263332NP_034833Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.2lef: LEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene. Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1). LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia and other kinds of malignancies like colorectal cancer. It is also a promising potential drug target. Lymphoid enhancer-binding factor 1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.