BECN1

2P1L, 2PON, 3DVU, 4DDP, 4MI8867856208ENSG00000126581ENSMUSG00000035086Q14457O88597NM_001313998NM_001313999NM_001314000NM_003766NM_019584NM_001359819NM_001359820NM_001359821NP_001300927NP_001300928NP_001300929NP_003757NP_062530NP_001346748NP_001346749NP_001346750Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6)  and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.2p1l: Structure of the Bcl-XL:Beclin 1 complex Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6)  and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death. Beclin-1 plays an important role in tumorigenesis, and neurodegeneration, being implicated in the autophagic programmed cell death. Ovarian cancer with upregulated autophagy has a less aggressive behavior and is more responsive to chemotherapy. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death. BECN1 has been shown to interact with: