Cross–McKusick–Breen syndrome (also known as 'Cross syndrome', 'hypopigmentation and microphthalmia', and 'oculocerebral-hypopigmentation syndrome') is an extremely rare disorder characterized by white skin, blond hair with yellow-gray metallic sheen, small eyes with cloudy corneas, jerky nystagmus, gingival fibromatosis and severe intellectual disability and physical retardation.:867–8 Cross–McKusick–Breen syndrome (also known as 'Cross syndrome', 'hypopigmentation and microphthalmia', and 'oculocerebral-hypopigmentation syndrome') is an extremely rare disorder characterized by white skin, blond hair with yellow-gray metallic sheen, small eyes with cloudy corneas, jerky nystagmus, gingival fibromatosis and severe intellectual disability and physical retardation.:867–8 It was characterized in 1967.