19-[(1′S,4′R)-4′-Hydroxy-1′-methoxy-2′-oxopentyl]geldanamycin, a Natural Geldanamycin Analogue from Streptomyces hygroscopicus 17997
2013
A novel natural geldanamycin analogue was discovered in Streptomyces hygroscopicus 17997. Its 4,5-dihydro form was also identified in the gdmP gene disruption mutant of Streptomyces hygroscopicus 17997. The structures of the two compounds were determined to be 19-[(1′S,4′R)-4′-hydroxy-1′-methoxy-2′-oxopentyl]geldanamycin (1) and 19-[(1′S,4′R)-4′-hydroxy-1′-methoxy-2′-oxopentyl]-4,5-dihydrogeldanamycin (2), respectively, by extensive spectroscopic data analysis, including 2D NMR, modified Mosher’s method, and electronic circular dichroism. Compared to geldanamycin, 1 and 2 showed increased water solubility and decreased cytotoxicity against HepG2 cells.
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