Yb(OTf)3-Mediated Annulation of Cyclopropane-1,1-dicarbonitriles with 2-Aminobenzaldehydes for Synthesis of Polysubstituted Quinolines.

A Yb(OTf)3-mediated annulation of cyclopropane-1,1-dicarbonitriles and 2-aminobenzaldehydes for the synthesis of polysubstituted quinolines in generally good yields was investigated. In the cascade reaction, the protocol includes ring opening, intermolecular nuclophilic addition, intramolecular nuclophilic addition, and demalononitrile aromatization, in which the malononitrile group serves as a deciduous directing group mediated by Yb(OTf)3.