Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

Artur Świerczek,Krzysztof Pociecha,Marietta Ślusarczyk,Grażyna Chłoń-Rzepa,Sebastian Baś,Jacek Mlynarski,Krzysztof Więckowski,Monika Zadrozna,Barbara Nowak,Elżbieta Wyska

Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach

2020

Artur Świerczek
Krzysztof Pociecha
Marietta Ślusarczyk
Grażyna Chłoń-Rzepa
Sebastian Baś
Jacek Mlynarski
Krzysztof Więckowski
Monika Zadrozna
Barbara Nowak
Elżbieta Wyska

Purpose This study aimed to assess the activity of two phosphodiesterase (PDE) inhibitors, namely GRMS-55 and racemic lisofylline ((±)-LSF)) in vitro and in animal models of immune-mediated disorders.

Keywords:

Chemistry
Pharmacology
Biochemistry
PK/PD models
Collagen-induced arthritis
Immune system
Phosphodiesterase
Lisofylline
Autoimmune hepatitis
In vitro

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