NMR and ESR approaches of biophysical properties of wild 'Sockeye' salmon oil

Sockeye salmon oil (SSO) is one of the richest natural sources of Omega 3. This oil also contains high amounts of astaxanthin, a strong antioxidant molecule. In the present work the physico-chemical properties of wild Alaskan Sockeye Salmon Oil were explored by NMR. The antioxidant propertieswere assessed by ESR in oldmice brain (24month) after 4 weeks feeding 100 µl/mouse, 5 Days/Week with Sockeye Salmon Oil. SSO exhibits interesting physicochemical and antioxidant properties: in aqueousmedium, SSO forms unilamellar or multilamellar droplets, and exhibits specific interactions with sphingomyelin (lowering of transition phase) and phosphatidylserine (fluidizing effect)membranes. Preliminary tests performed on aged mice showed a noticeable enhancement in health status (shinier fur, bitemarks,weight, explorative activity...) of chronicallySSOfed subjects, while ESR analysis found a decrease in the oxidative stress. The possible link between health status and a decrease of the local oxidative stress in brain upon SSO supplementation is discussed in terms of nutriprevention inAlzheimer disease.