5-member heterocycle and manufacturing method, pharmaceutical composition, and application thereof

The invention provides a 5-member heterocycle and a manufacturing method, pharmaceutical composition, and application thereof. Specifically, the invention provides a compound represented by formula (I). Various radicals are as defined in the specification. The compound represented by formula (I) is effective in inhibiting an activity of a tubulin and can be used to prepare a pharmaceutical product for treating or preventing a mammalian disease related to a tubulin abnormality.