Analysis of the Receptor Specificity of Influenza A Virus Strains Using the Method of Surface Plasmon Resonance

Abstract—The receptor specificity for the A/rook/Chany/32/2015 (H5N1), A/common gull/Saratov/1676/2018 (H5N6), and A/chicken/PrimorskyKrai/03/2018 (Н9N2) strains of avian influenza virus has been studied. Using the method of surface plasmon resonance for the selected strains we obtained the values ​​of the equilibrium dissociation constants with analogues of receptors such as α2-3 and α2-6. It was found that for strains A/rook/Chany/32/2015 (H5N1) and A/common gull/Saratov/1676/2018 (H5N6), a binding with the human type of receptor (α2-6) is determined, in contrast to the strain A/chicken/PrimorskyKrai/03/2018 (H9N2), which is specific only for avian type receptors (α2-3).