Ligands neuropeptide-y.

Compound of formula wherein A is O, S, or NR, wherein R is a lower alkyl (C1-C8); D is O, S or N-R7; W is N, CH or C-R8; R1 and R3 are independently H, alkyl C1-C14, linear or branched, cyclic or acyclic, saturated or unsaturated, optionally substituted by hydroxy, oxyalkyl short chain thioalkyl, oxyaryl or arylthio, wherein said groups bearing aryls they are optionally substituted by halogen, oxyalkyl short chain thioalkyl, lower alkyl, trifluoromethoxy, trifluoroethoxy or trifluoromethyl, and optionally said alkyl groups are substituted by cyclic structures selected from the group consisting of rings having a ring size of between 3 and 10 atoms, or the groups alkyl are substituted aromatic moieties or heteroaromatic, optionally containing said aryl or substituents heteroaryl groups on the aryl ring selected from the group consisting alquilode groups short-chain oxyalkyl, amino, aminoalkyl short chain aminoacyl short, halogen, trifluo chain and Rome linden or trifluoromethoxy; R2 is wherein W2 is C = O, SO2, C (O) NH; SW; or it is absent; Q is (a) a (-CH2-) z substituted or unsubstituted, where z = 1 to 12, and when -CH 2 is subs tituido, the substituents are alkyl groups of short chain, aryl or heteroaryl; and when z> 1, at least one -CH2- group is optionally replaced by a heteroatom selected from the group consis existent O, S or a substituted or unsubstituted N, wherein the portion is selected from the substituent group consisting of alkyl chain short, aryl, heteroarylalkyl and hydrogen; (B) a carbocyclic or saturated heterocyclic of the formula (-CH 2) x wherein I and m is 0-5, and where x = 3-12, preferably 3-8, and optionally one or more -CH2- groups - they are replaced with a radical selected from the group consisting of alkyl saturated or unsaturated short chain, cycloalkyl, aryl and heteroaryl; and optionally at least one of the CH2- groups is reem plazado by a heteroatom selected from the group consisting of O, S, Se and substituted or unsubstituted N, and when N is substituted, the substituent group is selected from the group consisting of alkyl short chain, aryl, heteroaryl and hydrogen; (C) a carbocyclic or heterocyclic formula (-CH = CH-) and wherein aromatic ring and m are 0-5, and wherein and optionally at least one of the -CH- groups is substituted by X1, X2 or both X1 X2 and wherein X is any cyclic substituent, for example saturated or unsaturated alkyl groups, linear or branched, oxyalkyls groups or halogens short chain, and optionally at least one of the -CH- groups is replaced by N, or alternatively , one of the -CH = CH- groups is replaced by a heteroatom selected from the group consisting of O, S, Se and N-R11; also optionally, at least one of the -CH = CH- groups is a junction to which may be fused another, either saturated or unsaturated cyclic structure, thus forming condensed aromatic systems or heteroaromatic selected, for example, from the group consisting classes of naphthalene, indole, benzofuran, quinoline, quinazoline and benzodioxane; X3 is a substituent on Q which can be H, lower alkyl, aryl, oxyalkyl short chain, hydroxy, trifluoromethyl, and the like and common cyclic substituents. R4 is selected from the group consisting of the following general formulas: wherein A1 is O, S, NH or N-lower alkyl or aryl; R5 to R9, R11 and R12 are independently selected from the group consisting of H, alkyl of C1 to C14, linear or branched, saturated or unsaturated, cyclic or acyclic, substituted or unsubstituted, or aryl radicals or heteroaryl, and when either R5 to R9, R11 or R12 is a substituted aryl or heteroaryl radical, the substituent group is selected from members grupoconsistente halogen, oxyalkyl short chain thioalkyl, lower alkyl, trifluoromethoxy and trifluoromethyl, and when any of the R5 to R9, R11 or R12 is an alkyl radical substituted, part substituent is selected from the group consisting of non-aromatic cyclic systems having from 3 to 14 ring atoms, and aromatic systems and heteroaromatic and heterocyclic rings having 4- 12 ring members, and said aromatic and heteroaromatic rings are optionally substituted by radicals selected from the group consisting of alk the short, oxyalkyl, amino, aminoalkyl short chain amidoacilo short, halogens, perfluoroalkyl chain and short chain perfluoroalkyl chain; or R6 is H, C1 to C14, linear or branched, cyclic or acyclic, saturated or unsaturated; aryl; heteroaryl; short chain arylalkyl; heteroarylalkyl short chain; arylalkyl short chain condensate; heteroarylalkyl short chain condensate; diarylalkyl short chain; bisheteroarilalquilo short chain; or short chain heteroarilalquilarilo; or partially or fully saturated derivatives thereof; or R6 can be R6 which is R6-NH-R6 or N-lower alkyl; R10 is hydrogen, alkyl groups of C1-C12, linear or branched, saturated or unsaturated, cyclic or acyclic, optionally containing double or triple bonds; aryl, optionally substituted with groups such as halogen, short chain oxyalkyl, aminoalkyl, dialkylaminoalkyl short chain hydroxy; arylalkyl; I oxyarylakyl; 2-tetrahydrofurfuryl; 3-tetrahydrofurfuryl; hidroxial terminal chyle with hydrocarbon chains and amidoalkyl C2-C10 such as 2-acetamidoethyl; or R9 and R10 may optionally form a ring of 3 to 10 members; and the compounds comprise any optically active isomer thereof as separated, pure or partially purified optical isomers or racemic mixtures thereof delos; and pharmaceutically acceptable salts thereof.