The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish.
2007
Background
Death receptors on the cell surface and the interacting cytosolic molecules, adaptors and initiator caspases, are essential as core components of the extrinsic apoptotic signaling pathway. While the apoptotic machinery governing the extrinsic signaling pathway is well characterized in mammals, it is not fully understood in fish.
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