Mature B cells are critical to T-cell-mediated tumor immunity induced by an agonist anti-GITR monoclonal antibody.

An agonistic antibody DTA-1, to glucocorticoid-induced TNFR-related protein (GITR), induces T-cell activation and antitumor immunity. CD4+ effector T cells are essential in initiating GITR-induced immune activation, and the sequentially activated cytolytic CD8+ T cells are sufficient to induce tumor