TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

The authors report that the cation channel TRPV1 suppresses excitatory synaptic transmission in dentate gyrus via a Ca2+-calcineurin and clathrin-dependent internalization of AMPA receptors. Activation of TRPV-1 triggers a form of LTD that is mediated by anandamide, but is independent of type 1 endocannabinoid receptors.