Mn(II), Co(II), Ni(II) and Zn salicylates: synthesis, structure and biological properties studies

Abstract Reaction of acetylsalicylic acid (aspirin) (H2L) with Mn(II), Co(II), Ni(II) and Zn acetates allow to obtain salicylates of related metals. The solid-state structures of prepared complexes were determined by single crystal X-ray crystallography and spectroscopic techniques. Zinc, nickel and cobalt(II) complexes are mononuclear and their crystal structures composed of neutral discrete molecules [Zn(sal)2(H2O)2], [Ni(sal)2(H2O)4] and [Co(sal)2(H2O)4] while manganese derivative has 2D polymeric structure. The cardiorespiratory and skin microcirculation activity of these metal complexes was evaluated. Particularly, the promising therapeutic activities displayed by 1-4 complexes make them potential candidates for the development of a promising drugs.