Movement errors during skilled motor performance engage distinct prediction error mechanisms

The brain detects deviations from intended behaviors by estimating the mismatch between predicted and actual outcomes. Axiomatic to these computations are salience and valence prediction error signals, which alert the brain to the occurrence and value of unexpected events. Despite the theoretical assertion of these prediction error signals, it is unknown whether and how brain mechanisms underlying their computations support error processing during skilled motor behavior. Here we demonstrate, with functional magnetic resonance imaging, that internal detection, i.e., without externally-provided feedback, of self-generated movement errors evokes instantaneous activity increases within the salience network and delayed lingering decreases within the nucleus accumbens – a key structure in the reward valuation pathway. A widespread suppression within the sensorimotor network was also observed. Our findings suggest that neural computations of salience and valence prediction errors during skilled motor behaviors operate on different time-scales and, therefore, may contribute differentially to immediate and longer-term adaptive processes. Ella Gabitov et al. use functional magnetic resonance imaging to identify changes in neural activity when participants commit an error in a motor sequence task. Their results suggest that two distinct neural circuits are involved in the processing of action errors: (1) the salience network that signals surprise and novelty, and (2) the reward pathway that plays a central role in motivation and incentive drive.