Isolation of Bisindole Alkaloids that Inhibit the Cell Cycle from Myxomycetes Arcyria ferruginea and Tubifera casparyi.

Abstract From a myxomycete Arcyria ferruginea , dihydroarcyriarubin C ( 1 ), a new bisindole alkaloid, has been isolated together with two known bisindoles, arcyriarubin C ( 2 ) and arcyriaflavin C ( 3 ), and arcyriaflavin C ( 3 ) was also isolated from Tubifera casparyi together with arcyriaflavin B ( 4 ). Arcyriaflavin C ( 3 ) exhibited cell cycle inhibition effect at G1 and G2/M stage at 10 and 100 ng/mL, respectively.