High Extracellular Calcium Affects Osteoclastogenesis in Mouse Bone Marrow Cell Culture

The effects of high extracellular calcium (highCa) in the local microenvironment onosteoclasts, osteoclast progenitors and stromalcells are not fully understood. We examined highCa effect on osteoclastogenesis in mouse bonemarrow cell culture. Mouse bone marrow cellswere cultured for up to 6 days in the medium sup-plemented with 1, 25(OH)