NH4I-Promoted N-acylation of amines via the transamidation of DMF and DMA under metal-free conditions

Abstract An unprecedented NH 4 I-promoted N -formylation and N -acetylization of various amines with dimethylformamide (DMF) and dimethylacetamide (DMA) has been developed. This protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic amines, which provides a metal-free strategy for N -acylation featuring mild reaction conditions, as well as inexpensive and readily available starting materials.