Alkynylation of cyclopropyl trifluoromethyl ketone catalyzed by CuF2·2H2O/4,7-diphenyl-1,10-phenanthroline
2017
Abstract CuF 2 ·2H 2 O/4,7-diphenyl-1,10-phenanthroline was found to be a highly efficient catalyst for the nucleophilic alkynylation of cyclopropyl trifluoromethyl ketone. The corresponding trifluoromethyl-substituted tertiary propargyl alcohols were synthesized in moderate to excellent yields under mild conditions. The catalyst system could also be applied to aromatic trifluoromethyl ketone as well as trifluoropyruvate.
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