Investigate Evaluation of Oxidative Stress and Lipid Profile in STZ-Induced Rats Treated with Antioxidant Vitamin

The objective of this study was designed to investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by showing significant changes in blood glucose, water, food intake, lipid profile, serum urea and ceratinine level, and antioxidant enzyme parameters activity. Streptozotocin (STZ)-induced toxicity was studied in male Waster rats; each divided into four groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ-induced diabetic rats (GIII), and STZ-induced diabetic rats treated with vitamin E (G1V). Moreover, vitamin E reduced (p f amount of total cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV). Vitamin prevented modification in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSX-Px) and in the concentration of the lipid hydroperoxide. Finally the study suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.