Dimeric L-Dopa Derivatives as Potential Prodrugs

Abstract A series of dimeric derivatives (+)- 1 , and (+)- 2 , and (+)- 3a–d of l -Dopa diacetyl esters was synthesized and evaluated as potential l -Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of l -Dopa in human plasma was observed.