Multidomain structure and correlated dynamics determined by self-consistent FRET networks

Björn Hellenkamp,Philipp Wortmann,Florian Kandzia,Martin Zacharias,Thorsten Hugel

Multidomain structure and correlated dynamics determined by self-consistent FRET networks

2017

Björn Hellenkamp
Philipp Wortmann
Florian Kandzia
Martin Zacharias
Thorsten Hugel

A hybrid approach merges networks of time-correlated distances determined by single-molecule FRET to uncover local and global dynamics of the multidomain protein Hsp90 in solution at multiple timescales.

Keywords:

Bioinformatics
Förster resonance energy transfer
Biology
Biophysics
hybrid approach
Molecular biology
Molecular dynamics
Protein domain
self consistent
Biological system
HSP90 Heat-Shock Proteins

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