Two-Dimensional photonic crystal Biosensors: A review

Abstract Photonic crystals are nanoscale structures that affect the motion of photons. The strong light limitation in photonic crystals and the adjustment of its structural parameters have led to the emergence of photonic crystal biosensors. Moreover, the use of holes as a feature of photonic crystals has resulted in sensors that are very sensitive to low refractive index changes with a small sensing area, which offers flexibility and integration on single-chip systems. Using emerging optofluidic technology, label-free biosensors are on the rise. In this review, we examine various types of photonic crystal sensors, such as waveguides, nanoresonators, LX resonators, holes, multi-channel resonators, nano RINGS resonators, and fibers. These sensors are based on the measurement of biomolecules and the refractive index properties that have been identified. Finally, a variety of challenges and guidelines for the construction of label-free diagnostic biosensors are examined.