Determination of 1-octanol-water partition coefficients for a group of 1,4-dihydropyridines by reversed-phase high performance liquid chromatography: Study of micellar liquid chromatography for hydrophobicity estimation

Abstract 1-Octanol-water partition coefficients (Pow) were determined for a group of 1,4-dihydropyridines by the classical extraction method called “shake-flask” method. Reversed-Phase High Performance Liquid Chromatography (RP-HPLC) was employed to determine the concentration of each solute in the aqueous phase after equilibrium. Micellar Liquid Chromatography (MLC) was used to obtain chromatographic parameters (k′, logk′, k′m, logk′m, Pmw, and logPmw) which were tested as hydrophobicity descriptors for the dihydropyridines studied. The correlation of these parameters with logPow was studied. Sodium Dodecyl Sulphate and Hexadecyltrimethylammonium Bromide modified by n-propanol or n-butanol were used as micellar systems in MLC.