COMPLETE REVIEW ON: MUCOADHESIVE MICROSPHERES

There are various approaches for the delivery of therapeutic substance to the target site in a controlled release fashion. One such approach is using microspheres as carriers for drugs or active pharmaceutical compound. However, the success of this drug delivery system is limited due to their short residence time at the site of absorption. Mucoadhesive microspheres can be tailored to adhere to any mucosal tissue including those found in stomach, thus offering the possibilities of localized as well as systemic controlled release of drugs. Mucoadhesive drug delivery systems promises several advantages that arise from localization at a given target site, prolonged residence time at the site of drug absorption and an intensified contact with the mucosal increasing the drug concentration gradient. The present review compiles mucoadhesion, theories of mucoadhesion, methods of preparation and applications of mucoadhesive microspheres.