Two flavonoid derivatives from the wood of Nangkadak (Moraceae)

Artocarpus is one of the essential genera of family Moraceae which is known as a rich source of flavonoids. As part of our investigation on the phenolic compounds of Indonesian Artocarpus and their antioxidant activities, we are now investigating flavonoids derivatives from the wood of Nangkadak. Nangkadak is the result of a cross between a female mini jackfruit (Artocarpus heterophyllus) and male broodstock from cempedak (Artocarpus integer). In this paper, we report the isolation of two flavonoid derivatives, namely Cycloartokarpin (1) and Artocarpin (2), using several methods of chromatography from this Artocarpus. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy. The antioxidant activity of 1 and 2 against 2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 160 ppm and 40.64 ppm, respectively. The result of antioxidant activity showed that 2 have potential activity as an antioxidant.