More than a FAD: The In Vivo Effects of Disease-Linked Presenilin-1 Mutations

Mutations in presenilins are linked to familial autosomal dominant Alzheimer's disease. In this issue of Neuron , Xia et al. (2015) show that a disease-linked mutation leads to loss of γ-secretase function, cognitive decline, and neurodegeneration when knocked into the mouse genome.