Total synthesis of tryprostatin A and B as well as their enantiomers

Abstract The 3-methylindoles 3a, 3b were converted into tryprostatin A ( 1a ), B ( 1b ) and their enantiomers 2a, 2b via prenylation at the indole 2-position by generation of the required 2-lithioindole derivatives (from 7a, 7b ), followed by alkylation.