Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion
2014
Defined phospholipid-functionalized glycopolymers serve as a new tool to identify the mechanistic connection between hypersialylation and immunoprotection, where hypersialylation of tumor cells subverts the immunosurveillance mechanism of NK cells by recruiting the lectin Siglec-7 to inhibit human NK cell activation.
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